STRATEGIES FOR DELIVERY - I: Synthesis and Applications of Endcapped Oligonucleotides II: Synthesis and Delivery of Amine and Guanidinium Functionalized Gold Nanoparticles
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9783639134520 - Pei-Sze Ng: STRATEGIES FOR DELIVERY: I: Synthesis and Applications of Endcapped Oligonucleotides II: Synthesis and Delivery of Amine and Guanidinium Functionalized Gold Nanoparticles
Pei-Sze Ng

STRATEGIES FOR DELIVERY: I: Synthesis and Applications of Endcapped Oligonucleotides II: Synthesis and Delivery of Amine and Guanidinium Functionalized Gold Nanoparticles (2009)

Lieferung erfolgt aus/von: Vereinigte Staaten von Amerika EN PB US

ISBN: 9783639134520 bzw. 3639134524, in Englisch, 176 Seiten, VDM Verlag, Taschenbuch, gebraucht.

125,62 ($ 134,20)¹ + Versand: 15,87 ($ 16,95)¹ = 141,49 ($ 151,15)¹
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Part I: Endcaps are linkers that link the 3? and 5? ends of DNA duplexes. A series of diamide endcaps has been synthesized and shown to stabilize DNA duplexes (4 base-pair). Endcapped CpG oligonucleotides were synthesized to elucidate the mode of recognition of different forms of CpG oligonucleotides by the immune system. Endcapped CpG oligonucleotides stimulated IL-6 and IL-12 secretion and extended the life span of the tumor implanted mice beyond that of the untreated control mice. Closed endcapped DNA duplexes were obtained by enzymatic ligation of the nicked DNA duplexes. The efficiency of ligation was dependent on the number of nucleotides flanking the 3?- and 5? ends of the nick. The nuclease stability of endcapped CpG oligonucleotides was established to be at least 6- fold more stable than unmodified oligonucleotides. Part II: Thiol terminated amine and guanidinium derivatives were synthesized and conjugated to 5 nm and 10 nm gold nanoparticles. These functionalized gold colloids were studied for their cellular uptake. Paperback, Label: VDM Verlag, VDM Verlag, Kumpulan produk: Book, Diterbitkan: 2009-03-27, Studio: VDM Verlag.
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9783639134520 - Pei-Sze Ng: STRATEGIES FOR DELIVERY
Pei-Sze Ng

STRATEGIES FOR DELIVERY

Lieferung erfolgt aus/von: Vereinigtes Königreich Großbritannien und Nordirland EN PB NW

ISBN: 9783639134520 bzw. 3639134524, in Englisch, VDM Verlag, Taschenbuch, neu.

59,49 ($ 63,55)¹
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Part I: Endcaps are linkers that link the 3' and 5' ends of DNA duplexes. A series of diamide endcaps has been synthesized and shown to stabilize DNA duplexes (4 base-pair). Endcapped CpG oligonucleotides were synthesized to elucidate the mode of recognition of different forms of CpG oligonucleotides by the immune system. Endcapped CpG oligonucleotides stimulated IL-6 and IL-12 secretion and extended the life span of the tumor implanted mice beyond that of the untreated control mice. Closed endcapped DNA duplexes were obtained by enzymatic ligation of the nicked DNA duplexes. The efficiency of ligation was dependent on the number of nucleotides flanking the 3'- and 5' ends of the nick. The nuclease stability of endcapped CpG oligonucleotides was established to be at least 6- fold more stable than unmodified oligonucleotides. Part II: Thiol terminated amine and guanidinium derivatives were synthesized and conjugated to 5 nm and 10 nm gold nanoparticles. These functionalized gold colloids were studied for their cellular uptake.
3
9783639134520 - Pei-Sze Ng: STRATEGIES FOR DELIVERY: I: Synthesis and Applications of Endcapped Oligonucleotides II: Synthesis and Delivery of Amine and Guanidinium Functionalized Gold Nanoparticles
Pei-Sze Ng

STRATEGIES FOR DELIVERY: I: Synthesis and Applications of Endcapped Oligonucleotides II: Synthesis and Delivery of Amine and Guanidinium Functionalized Gold Nanoparticles (2009)

Lieferung erfolgt aus/von: Vereinigtes Königreich Großbritannien und Nordirland EN PB NW

ISBN: 9783639134520 bzw. 3639134524, in Englisch, 176 Seiten, VDM Verlag, Taschenbuch, neu.

61,71 (£ 52,88)¹
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Lieferung aus: Vereinigtes Königreich Großbritannien und Nordirland, Usually dispatched within 1-2 business days, termasuk penghantaran (jika dihantar).
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9783639134520 - Pei-Sze Ng: STRATEGIES FOR DELIVERY: I: Synthesis and Applications of Endcapped Oligonucleotides II: Synthesis and Delivery of Amine and Guanidinium Functionalized Gold Nanoparticles
Pei-Sze Ng

STRATEGIES FOR DELIVERY: I: Synthesis and Applications of Endcapped Oligonucleotides II: Synthesis and Delivery of Amine and Guanidinium Functionalized Gold Nanoparticles (2009)

Lieferung erfolgt aus/von: Vereinigtes Königreich Großbritannien und Nordirland EN PB NW

ISBN: 9783639134520 bzw. 3639134524, in Englisch, 176 Seiten, VDM Verlag, Taschenbuch, neu.

73,52 (£ 63,00)¹ + Versand: 9,90 (£ 8,48)¹ = 83,42 (£ 71,48)¹
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9783639134520 - Pei-Sze Ng: STRATEGIES FOR DELIVERY: I: Synthesis and Applications of Endcapped Oligonucleotides II: Synthesis and Delivery of Amine and Guanidinium Functionalized Gold Nanoparticles
Pei-Sze Ng

STRATEGIES FOR DELIVERY: I: Synthesis and Applications of Endcapped Oligonucleotides II: Synthesis and Delivery of Amine and Guanidinium Functionalized Gold Nanoparticles (2009)

Lieferung erfolgt aus/von: Vereinigtes Königreich Großbritannien und Nordirland EN PB US

ISBN: 9783639134520 bzw. 3639134524, in Englisch, 176 Seiten, VDM Verlag, Taschenbuch, gebraucht.

68,58 (£ 58,77)¹
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Lieferung aus: Vereinigtes Königreich Großbritannien und Nordirland, Usually dispatched within 2-3 business days, termasuk penghantaran (jika dihantar).
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9783639134520 - Ng: STRATEGIES FOR DELIVERY
Ng

STRATEGIES FOR DELIVERY (2009)

Lieferung erfolgt aus/von: Deutschland ~EN PB NW

ISBN: 9783639134520 bzw. 3639134524, vermutlich in Englisch, VDM Verlag Dr. Müller, Saarbrücken, Deutschland, Taschenbuch, neu.

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