Human nasal primary cell cultures for peptide delivery studies
8 Angebote vergleichen
Bester Preis: € 47,79 (vom 26.02.2019)1
Symbolbild
Human nasal primary cell cultures for peptide delivery studies (Paperback) (2016)
DE PB NWISBN: 9783659824913 bzw. 3659824917, in Deutsch, LAP Lambert Academic Publishing, Taschenbuch, neu.
Von Händler/Antiquariat, The Book Depository EURO [60485773], London, United Kingdom.
Language: English . Brand New Book. Many proteins and peptides possess biological activity that makes them highly specific and effective therapeutic agents. For the treatment of chronic diseases or disorders (e.g. diabetes, cancer, osteoporosis, etc), however, they cannot be orally administered due to a rapid hydrolysis of the peptide bonds by digestive proteases. This work was done to explore the nasal route as a promising alternative to parenteral injections for systemic delivery of proteins and peptides due to its high vascularity of the mucosa, large surface area, avoidance of first-pass metabolism, ease of drug administration and high systemic bioavailability. Four primary culture systems of human nasal epithelium (i.e. immersion, air-liquid interface, floating collagen and sequential monolayer-suspension) were compared for peptide absorption and metabolism studies. Although these cell culture models are not identical with the epithelial cells under in vivo situation, the results reported in this book highlight the biopharmaceutical relevance of collagen-based human nasal primary cell culture systems as models for mechanistic assessment of nasal drug delivery.
Language: English . Brand New Book. Many proteins and peptides possess biological activity that makes them highly specific and effective therapeutic agents. For the treatment of chronic diseases or disorders (e.g. diabetes, cancer, osteoporosis, etc), however, they cannot be orally administered due to a rapid hydrolysis of the peptide bonds by digestive proteases. This work was done to explore the nasal route as a promising alternative to parenteral injections for systemic delivery of proteins and peptides due to its high vascularity of the mucosa, large surface area, avoidance of first-pass metabolism, ease of drug administration and high systemic bioavailability. Four primary culture systems of human nasal epithelium (i.e. immersion, air-liquid interface, floating collagen and sequential monolayer-suspension) were compared for peptide absorption and metabolism studies. Although these cell culture models are not identical with the epithelial cells under in vivo situation, the results reported in this book highlight the biopharmaceutical relevance of collagen-based human nasal primary cell culture systems as models for mechanistic assessment of nasal drug delivery.
2
Human nasal primary cell cultures for peptide delivery studies (2016)
DE PB NWISBN: 9783659824913 bzw. 3659824917, in Deutsch, 96 Seiten, LAP Lambert Academic Publishing, Taschenbuch, neu.
Lieferung aus: Deutschland, Versandkosten nach: Deutschland, Versandkostenfrei.
Von Händler/Antiquariat, Syndikat Buchdienst, [4235284].
Many proteins and peptides possess biological activity that makes them highly specific and effective therapeutic agents. For the treatment of chronic diseases or disorders (e.g. diabetes, cancer, osteoporosis, etc), however, they cannot be orally administered due to a rapid hydrolysis of the peptide bonds by digestive proteases. This work was done to explore the nasal route as a promising alternative to parenteral injections for systemic delivery of proteins and peptides due to its high vascularity of the mucosa, large surface area, avoidance of first-pass metabolism, ease of drug administration and high systemic bioavailability. Four primary culture systems of human nasal epithelium (i.e. immersion, air-liquid interface, floating collagen and sequential monolayer-suspension) were compared for peptide absorption and metabolism studies. Although these cell culture models are not identical with the epithelial cells under in vivo situation, the results reported in this book highlight the biopharmaceutical relevance of collagen-based human nasal primary cell culture systems as models for mechanistic assessment of nasal drug delivery. 2016, Taschenbuch / Paperback, Neuware, H: 220mm, B: 150mm, 96, Internationaler Versand, Selbstabholung und Barzahlung, PayPal, offene Rechnung, Banküberweisung.
Von Händler/Antiquariat, Syndikat Buchdienst, [4235284].
Many proteins and peptides possess biological activity that makes them highly specific and effective therapeutic agents. For the treatment of chronic diseases or disorders (e.g. diabetes, cancer, osteoporosis, etc), however, they cannot be orally administered due to a rapid hydrolysis of the peptide bonds by digestive proteases. This work was done to explore the nasal route as a promising alternative to parenteral injections for systemic delivery of proteins and peptides due to its high vascularity of the mucosa, large surface area, avoidance of first-pass metabolism, ease of drug administration and high systemic bioavailability. Four primary culture systems of human nasal epithelium (i.e. immersion, air-liquid interface, floating collagen and sequential monolayer-suspension) were compared for peptide absorption and metabolism studies. Although these cell culture models are not identical with the epithelial cells under in vivo situation, the results reported in this book highlight the biopharmaceutical relevance of collagen-based human nasal primary cell culture systems as models for mechanistic assessment of nasal drug delivery. 2016, Taschenbuch / Paperback, Neuware, H: 220mm, B: 150mm, 96, Internationaler Versand, Selbstabholung und Barzahlung, PayPal, offene Rechnung, Banküberweisung.
3
Symbolbild
Human nasal primary cell cultures for peptide delivery studies (2016)
DE PB NW RPISBN: 9783659824913 bzw. 3659824917, in Deutsch, Lap Lambert Academic Publishing, Taschenbuch, neu, Nachdruck.
Von Händler/Antiquariat, English-Book-Service Mannheim [1048135], Mannheim, Germany.
This item is printed on demand for shipment within 3 working days.
This item is printed on demand for shipment within 3 working days.
4
Symbolbild
Human nasal primary cell cultures for peptide delivery studies (2016)
DE PB NW RPISBN: 9783659824913 bzw. 3659824917, in Deutsch, LAP Lambert Academic Publishing, Taschenbuch, neu, Nachdruck.
Lieferung aus: Deutschland, Versandkostenfrei.
Von Händler/Antiquariat, European-Media-Service Mannheim [1048135], Mannheim, Germany.
This item is printed on demand for shipment within 3 working days.
Von Händler/Antiquariat, European-Media-Service Mannheim [1048135], Mannheim, Germany.
This item is printed on demand for shipment within 3 working days.
6
Human nasal primary cell cultur (2016)
DE PB NWISBN: 9783659824913 bzw. 3659824917, in Deutsch, Taschenbuch, neu.
Lieferung aus: Deutschland, Next Day, Versandkostenfrei.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
7
Human nasal primary cell cultures for peptide delivery studies (2016)
EN PB NWISBN: 9783659824913 bzw. 3659824917, in Englisch, 96 Seiten, LAP LAMBERT Academic Publishing, Taschenbuch, neu.
Lieferung aus: Deutschland, Gewöhnlich versandfertig in 24 Stunden, Versandkostenfrei. Tatsächliche Versandkosten können abweichen.
Von Händler/Antiquariat, averdo24.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Von Händler/Antiquariat, averdo24.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
8
Symbolbild
Human nasal primary cell cultures for peptide delivery studies
DE NWISBN: 9783659824913 bzw. 3659824917, in Deutsch, neu.
Lieferung aus: Deutschland, Versandkosten nach: Deutschland, Versandkostenfrei.
Von Händler/Antiquariat, Magazin Aziya, [3458207].
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Von Händler/Antiquariat, Magazin Aziya, [3458207].
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Lade…