Meta-Analysis of the Association of Nrxn1 Variants and Psychotic Spectrum Disorders (Paperback)
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Von Händler/Antiquariat, The Book Depository EURO [60485773], London, United Kingdom.
Language: English. Brand new Book. Academic Paper from the year 2017 in the subject Medicine - Neurology, Psychiatry, Addiction, grade: -, University of Murcia, language: English, abstract: Objective: To perform a meta-analysis of all published genetic association studies of NRNX1 variants and psychotic spectrum disorders (PSD). Methods: Potential studies were identified through PubMed/MEDLINE, EMBASE, HuGeNet, GeneCard and WoS up from 1980 until June 2015 (week 5). Published observational studies reporting NRXN1 variants in PSD cases and in non-PSD controls were all considered eligible for inclusion in this systematic review. Two reviewers selected studies for possible inclusion and extracted data independently following a standardized protocol. Different meta-analyses were performed for each NRXN1 variant and PSD and controls, with a random-effect model to calculate the pooled OR and its corresponding 95% CI. Forest plots and Cochran's Q-Statistic and I2 index were calculated to check for heterogeneity. Subgroup analyses and chi-square test were carried out to analyze potential moderators. Publication bias and quality of reporting were also analyzed. Results: 19 studies met our inclusion criteria, providing a total sample of 25208 patients with PSD and 56971 controls. Meta-analyses of NRXN1 deletions (OR = 3.36), exons (OR = 3.53) and introns (OR = 2.02) showed evidence of an association between NRXN1 gene and PSD. Only one study influed in a meta-analysis (NRXN1 deletions) and no quality criterion affected as moderating variable. There was evidence of potential publication bias in NRXN1 deletions, exonic and promoter meta-analyses. Conclusions: We found association between some variants of the NRXN1 gene and PSD. It s important to develop a greater effort for the study of the NRXN1 gene and bigger number of studies that will clarify it s association. The appendix is in Spanish.

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Von Händler/Antiquariat, buecher.de GmbH & Co. KG, [1].
Academic Paper from the year 2017 in the subject Medicine - Neurology, Psychiatry, Addiction, grade: -, University of Murcia, language: English, abstract: Objective: To perform a meta-analysis of all published genetic association studies of NRNX1 variants and psychotic spectrum disorders (PSD). Methods: Potential studies were identified through PubMed/MEDLINE, EMBASE, HuGeNet, GeneCard and WoS up from 1980 until June 2015 (week 5). Published observational studies reporting NRXN1 variants in PSD cases and in non-PSD controls were all considered eligible for inclusion in this systematic review. Two reviewers selected studies for possible inclusion and extracted data independently following a standardized protocol. Different meta-analyses were performed for each NRXN1 variant and PSD and controls, with a random-effect model to calculate the pooled OR and its corresponding 95% CI. Forest plots and Cochran's Q-Statistic and I2 index were calculated to check for heterogeneity. Subgroup analyses and chi-square test were carried out to analyze potential moderators. Publication bias and quality of reporting were also analyzed. Results: 19 studies met our inclusion criteria, providing a total sample of 25208 patients with PSD and 56971 controls. Meta-analyses of NRXN1 deletions (OR = 3.36), exons (OR = 3.53) and introns (OR = 2.02) showed evidence of an association between NRXN1 gene and PSD. Only one study influed in a meta-analysis (NRXN1 deletions) and no quality criterion affected as moderating variable. There was evidence of potential publication bias in NRXN1 deletions, exonic and promoter meta-analyses. Conclusions: We found association between some variants of the NRXN1 gene and PSD. It s important to develop a greater effort for the study of the NRXN1 gene and bigger number of studies that will clarify it s association. The appendix is in Spanish. 2018. 68 S. 210 mm Versandfertig in 3-5 Tagen, Softcover, Neuware, offene Rechnung (Vorkasse vorbehalten).

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Von Händler/Antiquariat, LitoA Buch- und Medienhandel.
Taschenbuch, Label: GRIN Verlag, GRIN Verlag, Produktgruppe: Book, Publiziert: 2018-08-31, Studio: GRIN Verlag.